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How to Become Top Fashion Designer You know you're destined to be a fashion designer if you: a) spent most of your childhood making clothes for your Barbie dolls instead of playing with your friends; b) read fashion magazines instead of your school books; c) ran a boutique out of your basement at age 10. In other words: if you want to be the next Yves Saint Laurent, it helps to be completely and utterly obsessed with fashion. Taking Manic Depression Effects Seriously Manic depression effects or Bipolar depression is actually considered as one of the worst type of depression that people usually suffer from. Characterized by sudden and extreme changes in their mood, Manic depression is said to be called as such because manic = mania refers to the 'ups' while depression refers to the 'downs'.